Mitochondria as a Therapeutic Target in Heart Failure
نویسندگان
چکیده
منابع مشابه
Mitochondria as a therapeutic target in heart failure.
Heart failure is a pressing public health problem with no curative treatment currently available. The existing therapies provide symptomatic relief, but are unable to reverse molecular changes that occur in cardiomyocytes. The mechanisms of heart failure are complex and multiple, but mitochondrial dysfunction appears to be a critical factor in the development of this disease. Thus, it is import...
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HEART FAILURE, THE ULTIMATUM of various forms of myocardial disease, is associated with high mortality rate in this modern world (2). Multiple factors play important roles in the genesis of heart failure. The presence of left ventricular hypertrophy is a powerful predictor of the development of heart failure (3). It is believed that gradual deterioration of the hypertrophied left ventricle (LV)...
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Endothelium as a Therapeutic Target in Heart Failure Print ISSN: 0009-7322. Online ISSN: 1524-4539 Copyright © 1998 American Heart Association, Inc. All rights reserved. is published by the American Heart Association, 7272 Greenville Avenue, Dallas, TX 75231 Circulation doi: 10.1161/01.CIR.98.24.2652 1998;98:2652-2655 Circulation. http://circ.ahajournals.org/content/98/24/2652 World Wide Web at...
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Heart failure (HF) is a chronic progressive cardiac disease with high morbidity and mortality. A key pathophysiological feature of HF is chronic overexcitation of the sympathetic nervous system and release of catecholamines. The subsequent activation of cardiac β-adrenoceptors (β-ARs) results in molecular and structural changes that lead to cardiac hypertrophy, myocardial fibrosis, or electrome...
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ژورنال
عنوان ژورنال: Journal of the American College of Cardiology
سال: 2013
ISSN: 0735-1097
DOI: 10.1016/j.jacc.2012.08.1021